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Regulation of lifespan by sensory perception in Caenorhabditis elegans

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Listed:
  • Javier Apfeld

    (University of California at San Francisco)

  • Cynthia Kenyon

    (University of California at San Francisco)

Abstract

Caenorhabditis elegans senses environmental signals through ciliated sensory neurons located primarily in sensory organs in the head and tail. Cilia function as sensory receptors, and mutants with defective sensory cilia have impaired sensory perception1,2. Cilia are membrane-bound microtubule-based structures and in C. elegans are only found at the dendritic endings of sensory neurons3. Here we show that mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Our findings imply that sensory perception regulates the lifespan of this animal, and suggest that in nature, its lifespan may be regulated by environmental cues.

Suggested Citation

  • Javier Apfeld & Cynthia Kenyon, 1999. "Regulation of lifespan by sensory perception in Caenorhabditis elegans," Nature, Nature, vol. 402(6763), pages 804-809, December.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6763:d:10.1038_45544
    DOI: 10.1038/45544
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    Cited by:

    1. Caroline Beaudoin-Chabot & Lei Wang & Cenk Celik & Aishah Tul-Firdaus Abdul Khalid & Subhash Thalappilly & Shiyi Xu & Jhee Hong Koh & Venus Wen Xuan Lim & Ann Don Low & Guillaume Thibault, 2022. "The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Paul W. Chrystal & Nils J. Lambacher & Lance P. Doucette & James Bellingham & Elena R. Schiff & Nicole C. L. Noel & Chunmei Li & Sofia Tsiropoulou & Geoffrey A. Casey & Yi Zhai & Nathan J. Nadolski & , 2022. "The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. Ivan Gusarov & Ilya Shamovsky & Bibhusita Pani & Laurent Gautier & Svetlana Eremina & Olga Katkova-Zhukotskaya & Alexander Mironov & Alexander А. Makarov & Evgeny Nudler, 2021. "Dietary thiols accelerate aging of C. elegans," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Alexandra Segref & Kavya L. Vakkayil & Tsimafei Padvitski & Qiaochu Li & Virginia Kroef & Jakob Lormann & Lioba Körner & Fabian Finger & Thorsten Hoppe, 2022. "Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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