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Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

Author

Listed:
  • Xiaoying Lin

    (The Institute for Genomic Research)

  • Samir Kaul

    (The Institute for Genomic Research)

  • Steve Rounsley

    (The Institute for Genomic Research
    Cereon Genomics)

  • Terrance P. Shea

    (The Institute for Genomic Research
    Cereon Genomics)

  • Maria-Ines Benito

    (The Institute for Genomic Research)

  • Christopher D. Town

    (The Institute for Genomic Research)

  • Claire Y. Fujii

    (The Institute for Genomic Research)

  • Tanya Mason

    (The Institute for Genomic Research)

  • Cheryl L. Bowman

    (The Institute for Genomic Research)

  • Mary Barnstead

    (The Institute for Genomic Research)

  • Tamara V. Feldblyum

    (The Institute for Genomic Research)

  • C. Robin Buell

    (The Institute for Genomic Research)

  • Karen A. Ketchum

    (The Institute for Genomic Research)

  • John Lee

    (The Institute for Genomic Research)

  • Catherine M. Ronning

    (The Institute for Genomic Research)

  • Hean L. Koo

    (The Institute for Genomic Research)

  • Kelly S. Moffat

    (The Institute for Genomic Research)

  • Lisa A. Cronin

    (The Institute for Genomic Research)

  • Mian Shen

    (The Institute for Genomic Research)

  • Grace Pai

    (The Institute for Genomic Research)

  • Susan Van Aken

    (The Institute for Genomic Research)

  • Lowell Umayam

    (The Institute for Genomic Research)

  • Luke J. Tallon

    (The Institute for Genomic Research)

  • John E. Gill

    (The Institute for Genomic Research)

  • Mark D. Adams

    (The Institute for Genomic Research
    Celera Genomics Corporation)

  • Ana J. Carrera

    (The Institute for Genomic Research)

  • Todd H. Creasy

    (The Institute for Genomic Research)

  • Howard M. Goodman

    (The Institute for Genomic Research
    Massachusetts General Hospital)

  • Chris R. Somerville

    (The Institute for Genomic Research
    Carnegie Institution of Washington)

  • Greg P. Copenhaver

    (The Institute for Genomic Research
    University of Chicago)

  • Daphne Preuss

    (The Institute for Genomic Research
    University of Chicago)

  • William C. Nierman

    (The Institute for Genomic Research)

  • Owen White

    (The Institute for Genomic Research)

  • Jonathan A. Eisen

    (The Institute for Genomic Research)

  • Steven L. Salzberg

    (The Institute for Genomic Research)

  • Claire M. Fraser

    (The Institute for Genomic Research)

  • J. Craig Venter

    (The Institute for Genomic Research
    Celera Genomics Corporation)

Abstract

Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130–140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and 16 megabases (Mb). The latter represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date. Chromosome 2 represents 15% of the genome and encodes 4,037 genes, 49% of which have no predicted function. Roughly 250 tandem gene duplications were found in addition to large-scale duplications of about 0.5 and 4.5 Mb between chromosomes 2 and 1 and between chromosomes 2 and 4, respectively. Sequencing of nearly 2 Mb within the genetically defined centromere revealed a low density of recognizable genes, and a high density and diverse range of vestigial and presumably inactive mobile elements. More unexpected is what appears to be a recent insertion of a continuous stretch of 75% of the mitochondrial genome into chromosome 2.

Suggested Citation

  • Xiaoying Lin & Samir Kaul & Steve Rounsley & Terrance P. Shea & Maria-Ines Benito & Christopher D. Town & Claire Y. Fujii & Tanya Mason & Cheryl L. Bowman & Mary Barnstead & Tamara V. Feldblyum & C. R, 1999. "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana," Nature, Nature, vol. 402(6763), pages 761-768, December.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6763:d:10.1038_45471
    DOI: 10.1038/45471
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