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Selecting and maintaining a diverse T-cell repertoire

Author

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  • Ananda W. Goldrath

    (University of Washington)

  • Michael J. Bevan

    (University of Washington)

Abstract

To provide a T-cell population that will respond promptly to foreign antigen, the immune system looks inward, using the variety of self-antigens to select and maintain a diverse repertoire of receptors. A protective immune system must include a T-lymphocyte population that is poised to respond to foreign antigenic peptides presented by self-major histocompatibility complex molecules. As the organism cannot predict the precise pathogen-derived antigens that will be encountered, the system uses the diverse array of self-peptides bound to self-major histocompatibility complex molecules, not only to select a receptor repertoire in the thymus, but also to keep naı ¨ve T cells alive and ‘ready for action’ in the periphery.

Suggested Citation

  • Ananda W. Goldrath & Michael J. Bevan, 1999. "Selecting and maintaining a diverse T-cell repertoire," Nature, Nature, vol. 402(6763), pages 6-13, December.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6763:d:10.1038_35005508
    DOI: 10.1038/35005508
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    Cited by:

    1. Yang, Ming & Park, Jeong-Man & Deem, Michael W., 2006. "A theory of multi-site vaccination for cancer," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 366(C), pages 347-364.

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