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Ubiquitin tag for sperm mitochondria

Author

Listed:
  • Peter Sutovsky

    (Oregon Health Sciences University)

  • Ricardo D. Moreno

    (International Center for Cancer Research and Developmental Biology)

  • João Ramalho-Santos

    (Center for Neuroscience, University of Coimbra)

  • Tanja Dominko

    (Oregon Health Sciences University)

  • Calvin Simerly

    (Oregon Health Sciences University)

  • Gerald Schatten

    (Oregon Health Sciences University)

Abstract

Like other mammals, humans inherit mitochondria from the mother only, even though the sperm contributes nearly one hundred mitochondria to the fertilized egg. In support of the idea that this strictly maternal inheritance of mitochondrial DNA arises from the selective destruction of sperm mitochondria1,2, we show here that sperm mitochondria inside fertilized cow and monkey eggs are tagged by the recycling marker protein ubiquitin3. This imprint is a death sentence that is written during spermatogenesis and executed after the sperm mitochondria encounter the egg's cytoplasmic destruction machinery.

Suggested Citation

  • Peter Sutovsky & Ricardo D. Moreno & João Ramalho-Santos & Tanja Dominko & Calvin Simerly & Gerald Schatten, 1999. "Ubiquitin tag for sperm mitochondria," Nature, Nature, vol. 402(6760), pages 371-372, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6760:d:10.1038_46466
    DOI: 10.1038/46466
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    Cited by:

    1. Sharon Ben-Hur & Shoshana Sernik & Sara Afar & Alina Kolpakova & Yoav Politi & Liron Gal & Anat Florentin & Ofra Golani & Ehud Sivan & Nili Dezorella & David Morgenstern & Shmuel Pietrokovski & Eyal S, 2024. "Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization," Nature Communications, Nature, vol. 15(1), pages 1-25, December.

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