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The role of allergy in the development of asthma

Author

Listed:
  • P. G. Holt

    (TVW Telethon Institute for Child Health Research, PO Box 855
    University of Western Australia)

  • C. Macaubas

    (TVW Telethon Institute for Child Health Research, PO Box 855
    University of Western Australia)

  • P. A. Stumbles

    (TVW Telethon Institute for Child Health Research, PO Box 855
    University of Western Australia)

  • P. D. Sly

    (TVW Telethon Institute for Child Health Research, PO Box 855
    University of Western Australia)

Abstract

Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to persistent atopic asthma, which may not manifest for several years, is restricted to only a subset of atopics. The key to establishing the link between atopy and asthma lies in the development of persistent inflammation in the airway wall, resulting in structural and functional changes in local tissues which are responsible for the symptoms of the disease. This review summarizes recent findings on the nature of the cellular and molecular mechanisms underlying this process, and addresses the issue of why the intensity and duration of these tissue-damaging responses in the airway wall apparently exceeds the critical threshold required for development of persistent asthma in only a minority of allergy sufferers.

Suggested Citation

  • P. G. Holt & C. Macaubas & P. A. Stumbles & P. D. Sly, 1999. "The role of allergy in the development of asthma," Nature, Nature, vol. 402(6760), pages 12-17, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6760:d:10.1038_35037009
    DOI: 10.1038/35037009
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    Cited by:

    1. Fahad M. Aldakheel, 2021. "Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics," IJERPH, MDPI, vol. 18(22), pages 1-29, November.

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