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The alliance of genes and environment in asthma and allergy

Author

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  • William Cookson

    (Wellcome Trust Centre for Human Genetics)

Abstract

The diseases of asthma, eczema and hay fever are typified by reactions to common allergens, which are mediated by immunoglobulin E. These allergic diseases are increasing in prevalence, and are now a major source of disability throughout the developed world. They are the result of complex interactions between largely unknown genetic and environmental mechanisms.The identification of the environmental factors offers the real possibility of prevention of disease, and unravelling the genetics of allergic illnesses is likely to change their classification and treatment. Early life seems particularly important, when the initiation of allergic disease may result from genetic and environmental modification of the immune interaction between mother and child.

Suggested Citation

  • William Cookson, 1999. "The alliance of genes and environment in asthma and allergy," Nature, Nature, vol. 402(6760), pages 5-11, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6760:d:10.1038_35037002
    DOI: 10.1038/35037002
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    Cited by:

    1. Thompson, Owen, 2014. "Genetic mechanisms in the intergenerational transmission of health," Journal of Health Economics, Elsevier, vol. 35(C), pages 132-146.
    2. Tania Dottorini & Gabriella Sole & Luisa Nunziangeli & Francesca Baldracchini & Nicola Senin & Giorgio Mazzoleni & Carla Proietti & Lenuta Balaci & Andrea Crisanti, 2011. "Serum IgE Reactivity Profiling in an Asthma Affected Cohort," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-11, August.
    3. Guangdie Yang & Junjun Chen & Fei Xu & Zhang Bao & Yake Yao & Jianying Zhou, 2014. "Association between Tumor Necrosis Factor-α rs1800629 Polymorphism and Risk of Asthma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-11, June.
    4. Laura Corlin & Mark Woodin & Danny Newhide & Erika Brown & Sarah Valentina Diaz & Amy Chi & Doug Brugge, 2013. "Asthma Associations in Children Attending a Museum of Science," IJERPH, MDPI, vol. 10(9), pages 1-15, September.

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