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A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance

Author

Listed:
  • Bernhard G. Herrmann

    (Max-Planck-Institute of Immunobiology)

  • Birgit Koschorz

    (Max-Planck-Institute of Immunobiology)

  • Karin Wertz

    (Max-Planck-Institute of Immunobiology)

  • K. John McLaughlin

    (Max-Planck-Institute of Immunobiology
    New Bolton Center)

  • Andreas Kispert

    (Max-Planck-Institute of Immunobiology)

Abstract

Males heterozygous for the t-haplotype form of mouse chromosome 17 preferentially transmit the t-chromosome to their progeny. Several distorter/sterility loci carried on the t-haplotype together impair flagellar function in all spermatozoa whereas the responder, Tcr, rescues t-sperm but not wild-type sperm. Thus, t-sperm have an advantage over wild-type sperm in fertilizing egg cells. We have isolated Tcr by positional cloning and show that it is a member of a novel protein kinase gene family, designated Smok, which is expressed late during spermiogenesis. Smok kinases are components of a signal cascade which may control sperm motility. Tcr has a reduced kinase activity, which may allow it to counterbalance a signalling impairment caused by the distorter/sterility loci. Tcr transgene constructs cause non-mendelian transmission of chromosomes on which they are carried, which leads to sex-ratio distortion when Tcr cosegregates with the Y chromosome.

Suggested Citation

  • Bernhard G. Herrmann & Birgit Koschorz & Karin Wertz & K. John McLaughlin & Andreas Kispert, 1999. "A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance," Nature, Nature, vol. 402(6758), pages 141-146, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6758:d:10.1038_45970
    DOI: 10.1038/45970
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    Cited by:

    1. Shimin You & Zhigang Zhao & Xiaowen Yu & Shanshan Zhu & Jian Wang & Dekun Lei & Jiawu Zhou & Jing Li & Haiyuan Chen & Yanjia Xiao & Weiwei Chen & Qiming Wang & Jiayu Lu & Keyi Chen & Chunlei Zhou & Xi, 2023. "A toxin-antidote system contributes to interspecific reproductive isolation in rice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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