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Mitochondrial DNA repairs double-strand breaks in yeast chromosomes

Author

Listed:
  • Miria Ricchetti

    (Unité de Physicochimie des Macromolécules Biologiques (URA1773 du CNRS), Institut Pasteur)

  • Cécile Fairhead

    (Unité de Génétique Moléculaire des Levures (URA1300 du CNRS, UFR 927 Université Pierre et Marie Curie), Institut Pasteur)

  • Bernard Dujon

    (Unité de Génétique Moléculaire des Levures (URA1300 du CNRS, UFR 927 Université Pierre et Marie Curie), Institut Pasteur)

Abstract

The endosymbiotic theory for the origin of eukaryotic cells1 proposes that genetic information can be transferred from mitochondria to the nucleus of a cell, and genes that are probably of mitochondrial origin have been found in nuclear chromosomes2. Occasionally, short or rearranged sequences homologous to mitochondrial DNA are seen in the chromosomes of different organisms including yeast, plants and humans3. Here we report a mechanism by which fragments of mitochondrial DNA, in single or tandem array, are transferred to yeast chromosomes under natural conditions during the repair of double-strand breaks in haploid mitotic cells. These repair insertions originate from non-contiguous regions of the mitochondrial genome. Our analysis of the Saccharomyces cerevisiae mitochondrial genome4 indicates that the yeast nuclear genome does indeed contain several short sequences of mitochondrial origin which are similar in size and composition to those that repair double-strand breaks. These sequences are located predominantly in non-coding regions of the chromosomes, frequently in the vicinity of retrotransposon long terminal repeats, and appear as recent integration events. Thus, colonization of the yeast genome by mitochondrial DNA is an ongoing process.

Suggested Citation

  • Miria Ricchetti & Cécile Fairhead & Bernard Dujon, 1999. "Mitochondrial DNA repairs double-strand breaks in yeast chromosomes," Nature, Nature, vol. 402(6757), pages 96-100, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6757:d:10.1038_47076
    DOI: 10.1038/47076
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    Cited by:

    1. Yang Yu & Xin Wang & Jordan Fox & Ruofan Yu & Pilendra Thakre & Brenna McCauley & Nicolas Nikoloutsos & Yang Yu & Qian Li & P. J. Hastings & Weiwei Dang & Kaifu Chen & Grzegorz Ira, 2024. "Yeast EndoG prevents genome instability by degrading extranuclear DNA species," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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