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See a pocket, block it

Author

Listed:
  • John P. Moore

    (the Aaron Diamond AIDS Research Center, The Rockefeller University)

  • Tatjana Dragic

    (the Aaron Diamond AIDS Research Center, The Rockefeller University)

Abstract

The focus of drugs for treating HIV-1 infection has switched from protease and reverse-transcriptase inhibitors to compounds that prevent fusion of the virus with human cells. The target protein in this pathway is known as gp41, and, last year, a pocket was identified in gp41 that could act as the binding site for a fusion inhibitor. Peptide inhibitors that specifically bind this pocket have now been identified.

Suggested Citation

  • John P. Moore & Tatjana Dragic, 1999. "See a pocket, block it," Nature, Nature, vol. 401(6755), pages 759-759, October.
    • Handle: RePEc:nat:nature:v:401:y:1999:i:6755:d:10.1038_44504
    DOI: 10.1038/44504
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