IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v401y1999i6751d10.1038_43830.html
   My bibliography  Save this article

Casein kinase I transduces Wnt signals

Author

Listed:
  • John M. Peters

    (Center for Developmental Biology, UT Southwestern Medical Center)

  • Renée M. McKay

    (Center for Developmental Biology, UT Southwestern Medical Center)

  • James P. McKay
  • Jonathan M. Graff

    (Center for Developmental Biology, UT Southwestern Medical Center)

Abstract

The Wnt signalling cascade is essential for the development of both invertebrates and vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling has been elucidated, not all of the components have been identified. Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression cloning in Xenopus embryos. CKI reproduces several properties of Wnt signals, including generation of complete dorsal axes, stabilization of β-catenin and induction of genes that are direct targets of Wnt signals. Dominant-negative forms of CKI and a pharmacological blocker of CKI inhibited Wnt signals in Xenopus. Inhibiting CKI in Caenorhabditis elegans generated worms with a mom phenotype, indicative of a loss of Wnt signals. In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway.

Suggested Citation

  • John M. Peters & Renée M. McKay & James P. McKay & Jonathan M. Graff, 1999. "Casein kinase I transduces Wnt signals," Nature, Nature, vol. 401(6751), pages 345-350, September.
    • Handle: RePEc:nat:nature:v:401:y:1999:i:6751:d:10.1038_43830
    DOI: 10.1038/43830
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/43830
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/43830?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:401:y:1999:i:6751:d:10.1038_43830. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.