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Tracking the evolution of insecticide resistance in the mosquito Culex pipiens

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  • Thomas Lenormand

    (Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution (UMR 5554), Université Montpellier II
    University of British Columbia)

  • Denis Bourguet

    (Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution (UMR 5554), Université Montpellier II
    INRA La Minière)

  • Thomas Guillemaud

    (Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution (UMR 5554), Université Montpellier II
    Lab. de biologia molecular, UCTRA, Universidade do Algarve)

  • Michel Raymond

    (Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution (UMR 5554), Université Montpellier II)

Abstract

The evolution of pesticide resistance provides some of the most striking examples of darwinian evolution occurring over a human life span. Identification of resistance alleles opens an outstanding framework in which to study the evolution of adaptive mutations from the beginning of pesticide application1,2,3, the evolution of interactions between alleles (dominance4) or between loci (epistasis5,6). Here we show that resistance alleles can also be used as markers to dissect population processes at a microevolutionary scale. We have focused on the antagonistic roles of selection and migration involved in the dynamics of local adaptation with reference to allelic frequencies at two resistance loci in the mosquito Culex pipiens. We find that their frequencies follow an annual cycle of large amplitude (25%), and we precisely unravel the seasonal variation of migration and selection underlying this cycle. Our results provide a firm basis on which to devise an insecticide treatment strategy that will better control the evolution of resistance genes and the growth of mosquito populations.

Suggested Citation

  • Thomas Lenormand & Denis Bourguet & Thomas Guillemaud & Michel Raymond, 1999. "Tracking the evolution of insecticide resistance in the mosquito Culex pipiens," Nature, Nature, vol. 400(6747), pages 861-864, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6747:d:10.1038_23685
    DOI: 10.1038/23685
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    Cited by:

    1. Thomas L. Schmidt & Nancy M. Endersby-Harshman & Anthony R. J. Rooyen & Michelle Katusele & Rebecca Vinit & Leanne J. Robinson & Moses Laman & Stephan Karl & Ary A. Hoffmann, 2024. "Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Nicholas Miller & Kyung Seok Kim & Susan T. Ratcliffe & Arnaud Estoup & Denis D. Bourguet & Thomas Guillemaud, 2006. "Absence of genetic divergence between western corn rootworms (Coleoptera : Chrysomelidae) resistant and susceptible to control by crop rotation," Post-Print hal-02657866, HAL.

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