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Myosin-V is a processive actin-based motor

Author

Listed:
  • Amit D. Mehta

    (Stanford University Medical Center)

  • Ronald S. Rock

    (Stanford University Medical Center)

  • Matthias Rief

    (Stanford University Medical Center)

  • James A. Spudich

    (Stanford University Medical Center)

  • Mark S. Mooseker

    (Cellular and Developmental Biology, Yale University)

  • Richard E. Cheney

    (University of North Carolina at Chapel Hill)

Abstract

Class-V myosins, one of 15 known classes of actin-based molecular motors, have been implicated in several forms of organelle transport1,2,3,4,5 perhaps working with microtubule-based motors such as kinesin2,3,4,6. Such movements may require a motor with mechanochemical properties distinct from those of myosin-II, which operates in large ensembles to drive high-speed motility as in muscle contraction7. Based on its function and biochemistry, it has been suggested that myosin-V may be a processive motor7,8 like kinesin9,10. Processivity means that the motor undergoes multiple catalytic cycles and coupled mechanical advances for each diffusional encounter with its track. This allows single motors to support movement of an organelle along its track. Here we provide direct evidence that myosin-V is indeed a processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament.

Suggested Citation

  • Amit D. Mehta & Ronald S. Rock & Matthias Rief & James A. Spudich & Mark S. Mooseker & Richard E. Cheney, 1999. "Myosin-V is a processive actin-based motor," Nature, Nature, vol. 400(6744), pages 590-593, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6744:d:10.1038_23072
    DOI: 10.1038/23072
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    Cited by:

    1. Lipowsky, Reinhard & Chai, Yan & Klumpp, Stefan & Liepelt, Steffen & Müller, Melanie J.I., 2006. "Molecular motor traffic: From biological nanomachines to macroscopic transport," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 372(1), pages 34-51.

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