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Directional guidance of neuronal migration in the olfactory system by the protein Slit

Author

Listed:
  • Wei Wu

    (Laboratory of Molecular Neurobiology, Shanghai Research Center for the Life Sciences and The National Institute of Neuroscience, The Chinese Academy of Sciences)

  • Kit Wong

    (Washington University School of Medicine)

  • Jin-hui Chen

    (Laboratory of Molecular Neurobiology, Shanghai Research Center for the Life Sciences and The National Institute of Neuroscience, The Chinese Academy of Sciences)

  • Zhi-hong Jiang

    (Washington University School of Medicine)

  • Sophie Dupuis

    (Washington University School of Medicine)

  • Jane Y. Wu

    (Washington University School of Medicine)

  • Yi Rao

    (Washington University School of Medicine)

Abstract

Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

Suggested Citation

  • Wei Wu & Kit Wong & Jin-hui Chen & Zhi-hong Jiang & Sophie Dupuis & Jane Y. Wu & Yi Rao, 1999. "Directional guidance of neuronal migration in the olfactory system by the protein Slit," Nature, Nature, vol. 400(6742), pages 331-336, July.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6742:d:10.1038_22477
    DOI: 10.1038/22477
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    Cited by:

    1. Matthias Vigelius & Bernd Meyer, 2012. "Multi-Dimensional, Mesoscopic Monte Carlo Simulations of Inhomogeneous Reaction-Drift-Diffusion Systems on Graphics-Processing Units," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-13, April.
    2. Parthasarathy Srinivasan & Ioannis K Zervantonakis & Chandrasekhar R Kothapalli, 2014. "Synergistic Effects of 3D ECM and Chemogradients on Neurite Outgrowth and Guidance: A Simple Modeling and Microfluidic Framework," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-15, June.

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