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Dating the origin of HIV-1 subtypes

Author

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  • Jaap Goudsmit

    (Academic Medical Center, University of Amsterdam)

  • Vladimir V. Lukashov

    (Academic Medical Center, University of Amsterdam)

Abstract

The moment in history when subtypes of the human immunodeficiency virus HIV-1 became distinguishable is hotly debated1,2. Zhu et al.3 have provided a unique HIV-1 sequence from 1959, known as ZR59. Based on the position of ZR59 in phylogenetic trees and its distance from the common node of the viral B/D/F-subtype lineages, they suggest that subtypes B and D have evolved from a single introduction “not long before 1959”, and that HIV-1 group M viruses probably shared a common ancestor “in the 1940s or the early 1950s”. Here we caution against such precise dating of these evolutionary events.

Suggested Citation

  • Jaap Goudsmit & Vladimir V. Lukashov, 1999. "Dating the origin of HIV-1 subtypes," Nature, Nature, vol. 400(6742), pages 325-326, July.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6742:d:10.1038_22454
    DOI: 10.1038/22454
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