IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v400y1999i6741d10.1038_22343.html
   My bibliography  Save this article

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

Author

Listed:
  • Xinhua Lin

    (Department of Genetics)

  • Norbert Perrimon

    (Howard Hughes Medical Institute, Harvard Medical School)

Abstract

The Drosophila wingless gene (wg) encodes a protein of the Wnt family and is a critical regulator in many developmental processes1. Biochemical studies have indicated that heparan sulphate proteoglycans, consisting of a protein core to which heparan sulphate glycosaminoglycans are attached2, are important for Wg function3. Here we show that, consistent with these findings, the Drosophila gene sulfateless (sfl), which encodes a homologue of vertebrate heparan sulphate N -deacetylase/N -sulphotransferase (an enzyme needed for the modification of heparan sulphate) is essential for Wg signalling. We have identified the product of division abnormally delayed (dally), a glycosyl-phosphatidyl inositol (GPI)-linked glypican, as a heparan sulphate proteoglycan molecule involved in Wg signalling. Our results indicate that Dally may act as a co-receptor for Wg, and that Dally, together with Drosophila Frizzled 2, modulates both short- and long-range activities of Wg.

Suggested Citation

  • Xinhua Lin & Norbert Perrimon, 1999. "Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling," Nature, Nature, vol. 400(6741), pages 281-284, July.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6741:d:10.1038_22343
    DOI: 10.1038/22343
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/22343
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/22343?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Fisun Hamaratoglu & Aitana Morton de Lachapelle & George Pyrowolakis & Sven Bergmann & Markus Affolter, 2011. "Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc," PLOS Biology, Public Library of Science, vol. 9(10), pages 1-17, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:400:y:1999:i:6741:d:10.1038_22343. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.