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Translating cell biology into therapeutic advances in Alzheimer's disease

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  • Dennis J. Selkoe

    (Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital)

Abstract

Studies of the molecular basis of Alzheimer's disease exemplify the increasingly blurred distinction between basic and applied biomedical research.The four genes so far implicated in familial Alzheimer's disease have each been shown to elevate brain levels of the self-aggregating amyloid-β protein, leading gradually to profound neuronal and glial alteration, synaptic loss and dementia. Progress in understanding this cascade has helped to identify specific therapeutic targets and provides a model for elucidating other neurodegenerative disorders.

Suggested Citation

  • Dennis J. Selkoe, 1999. "Translating cell biology into therapeutic advances in Alzheimer's disease," Nature, Nature, vol. 399(6738), pages 23-31, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6738:d:10.1038_399a023
    DOI: 10.1038/399a023
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    Cited by:

    1. Ornella Di Pietro & Jordi Juárez-Jiménez & Diego Muñoz-Torrero & Charles A Laughton & F Javier Luque, 2017. "Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-22, May.
    2. Manuel Lillo-Crespo & Mar Forner-Ruiz & Jorge Riquelme-Galindo & Daniel Ruiz-Fernández & Sofía García-Sanjuan, 2019. "Chess Practice as a Protective Factor in Dementia," IJERPH, MDPI, vol. 16(12), pages 1-12, June.

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