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The changing landscape of ischaemic brain injury mechanisms

Author

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  • Jin-Moo Lee

    (Washington University School of Medicine)

  • Gregory J. Zipfel

    (Washington University School of Medicine)

  • Dennis W. Choi

    (Washington University School of Medicine)

Abstract

Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

Suggested Citation

  • Jin-Moo Lee & Gregory J. Zipfel & Dennis W. Choi, 1999. "The changing landscape of ischaemic brain injury mechanisms," Nature, Nature, vol. 399(6738), pages 7-14, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6738:d:10.1038_399a007
    DOI: 10.1038/399a007
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    Cited by:

    1. Piotr Terlecki & Stanisław Przywara & Karol Terlecki & Dariusz Janczak & Maciej Antkiewicz & Tomasz Zubilewicz, 2022. "Effect of Reconstructive Procedures of the Extracranial Segment of the Carotid Arteries on Damage to the Blood–Brain Barrier," IJERPH, MDPI, vol. 19(10), pages 1-14, May.

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