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TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans

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  • L. E. Graves

    (Northwestern University Medical School)

  • S. Segal

    (Northwestern University Medical School)

  • E. B. Goodwin

    (Northwestern University Medical School)

Abstract

The GLI protein family is involved in several key developmental processes in both vertebrates and invertebrates. The Drosophila GLI protein, Cubitus interuptus (Ci), regulates segment polarity and wing and leg development. In vertebrates, the GLI proteins control neural, lung, bone and gut development1. In the nematode Caenorhabditis elegans, the GLI family member TRA-1 is necessary for normal sexual development2,3. GLI, Ci and TRA-1 each contain five zinc-finger domains and bind the identical DNA sequence. Previous analyses are consistent with these proteins being transcription factors4,5. Here we show that TRA-1 can act post-transcriptionally to govern gene activity. Our results indicate that the binding of TRA-1 to the 3′ untranslated region oftra-2 regulates the export of tra-2 messenger RNA from thenucleus. The fact that TRA-1 is part of a conserved family ofproteins raises the possibility that GLI family members are both transcriptional and post-transcriptional regulators of gene expression.

Suggested Citation

  • L. E. Graves & S. Segal & E. B. Goodwin, 1999. "TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans," Nature, Nature, vol. 399(6738), pages 802-805, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6738:d:10.1038_21682
    DOI: 10.1038/21682
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