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Decoding the Reelin signal

Author

Listed:
  • Isabelle Bar

    (Neurobiology Unit, University of Namur Medical School)

  • André M. Goffinet

    (Neurobiology Unit, University of Namur Medical School)

Abstract

Thereelermutant mouse has been used as a model of abnormal brain development for over 50 years. These mice lack a protein called Reelin, and they show a series of developmental abnormalities. Mice lacking two other proteins — the very low density lipoprotein receptor, and the apolipoprotein E receptor-2 — have now been found to show the same abnormalities, indicating that these molecules are involved in the Reelin signalling pathway.

Suggested Citation

  • Isabelle Bar & André M. Goffinet, 1999. "Decoding the Reelin signal," Nature, Nature, vol. 399(6737), pages 645-646, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6737:d:10.1038_21340
    DOI: 10.1038/21340
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