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Key to the mitochondrial gate

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  • Jean-Claude Martinou

    (Jean-Claude Martinou is at the Serono Pharmaceutical Research Institute)

Abstract

When cytochromec, which is normally localized in the mitochondria, escapes into the cytosol, it helps to activate the caspases (killer proteases) leading to cell death. New evidence indicates that the key to release of cytochrome c is the so-called voltage-dependent ion channel. Proteins that promote apoptosis seem to bind to this channel, causing it to change shape so that cytochrome ccan pass through.

Suggested Citation

  • Jean-Claude Martinou, 1999. "Key to the mitochondrial gate," Nature, Nature, vol. 399(6735), pages 411-412, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6735:d:10.1038_20804
    DOI: 10.1038/20804
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