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Many vessels, faulty gene

Author

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  • William G. Kaelin

    (Dana-Farber Cancer Institute
    Brigham and Womens Hospital
    Harvard Medical School)

Abstract

The von Hippel-Lindau (VHL) cancer syndrome is caused by mutations in theVHLgene, and is characterized by development of blood-vessel tumours. Production of blood vessels is normally stimulated when cells are short of oxygen. But when oxygen is plentiful, the factors that stimulate production of vessels are destroyed. It now turns out that the VHL protein is responsible for this destruction. So, when it is mutated, the result is too many vessels and tumour formation.

Suggested Citation

  • William G. Kaelin, 1999. "Many vessels, faulty gene," Nature, Nature, vol. 399(6733), pages 203-204, May.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6733:d:10.1038_20309
    DOI: 10.1038/20309
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