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Legs to wings and back again

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  • Lee Niswander

    (Memorial Sloan Kettering Cancer Center, and the Howard Hughes Medical Institute)

Abstract

How do arms or wings (forelimbs) become different from legs (hindlimbs)? It all hinges on the expression of specific transcription factors in the embryonic fore- or hindlimb buds. Expression of the Tbx5 protein in the chick results in the development of wings, whereas the Tbx4 protein specifies legs. Misexpression of these proteins generates wing-like legs and leg-like wings, respectively, and should tell us much about the mechanisms by which these proteins act.

Suggested Citation

  • Lee Niswander, 1999. "Legs to wings and back again," Nature, Nature, vol. 398(6730), pages 751-752, April.
    • Handle: RePEc:nat:nature:v:398:y:1999:i:6730:d:10.1038_19625
    DOI: 10.1038/19625
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