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Gatekeepers of recombination

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  • James E. Haber

    (Brandeis University)

Abstract

There are two main pathways by which chromosomal double-strand breaks are repaired — nonhomologous end-joining and homologous recombination. The 'gatekeeper' for the first of these processes is the Ku protein, and the warden of the second has now been identified as Rad52. The authors propose a model in which Rad52 and Ku compete to channel the broken ends down their respective pathways.

Suggested Citation

  • James E. Haber, 1999. "Gatekeepers of recombination," Nature, Nature, vol. 398(6729), pages 665-667, April.
    • Handle: RePEc:nat:nature:v:398:y:1999:i:6729:d:10.1038_19423
    DOI: 10.1038/19423
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    Cited by:

    1. Jun Huang & David Rowe & Pratima Subedi & Wei Zhang & Tyler Suelter & Barbara Valent & David E. Cook, 2022. "CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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