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Exposing the human nude phenotype

Author

Listed:
  • Jorge Frank

    (Columbia University)

  • Claudio Pignata

    (Unit of Immunology, Federico II University)

  • Andrei A. Panteleyev

    (Columbia University)

  • David M. Prowse

    (Harvard Medical School)

  • Howard Baden

    (Harvard Medical School)

  • Lorin Weiner

    (Harvard Medical School)

  • Lucia Gaetaniello

    (Unit of Immunology, Federico II University)

  • Wasim Ahmad

    (Columbia University)

  • Nicola Pozzi

    (Unit of Immunology, Federico II University)

  • Peter B. Cserhalmi-Friedman

    (Columbia University)

  • Vincent M. Aita

    (Genetics and Development, Columbia University)

  • Hendrik Uyttendaele

    (Columbia University)

  • Derek Gordon

    (Laboratory of Statistical Genetics, The Rockefeller University)

  • Jurg Ott

    (Laboratory of Statistical Genetics, The Rockefeller University)

  • Janice L. Brissette

    (Harvard Medical School)

  • Angela M. Christiano

    (Columbia University
    Genetics and Development, Columbia University)

Abstract

The recent discovery of the human counterpart of the hairless mouse phenotype1 has helped our understanding of the molecular genetics of hair growth. But there are no reports of a defect in the human homologue of the best known of the ‘bald’ mouse phenotypes, the nude mouse2. This may be because affected individuals are so gravely ill from the accompanying immunodeficiency that their baldness goes unnoticed. We have carried out a genetic analysis that reveals a human homologue of the nude mouse.

Suggested Citation

  • Jorge Frank & Claudio Pignata & Andrei A. Panteleyev & David M. Prowse & Howard Baden & Lorin Weiner & Lucia Gaetaniello & Wasim Ahmad & Nicola Pozzi & Peter B. Cserhalmi-Friedman & Vincent M. Aita & , 1999. "Exposing the human nude phenotype," Nature, Nature, vol. 398(6727), pages 473-474, April.
    • Handle: RePEc:nat:nature:v:398:y:1999:i:6727:d:10.1038_18997
    DOI: 10.1038/18997
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