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Molecular basis of triclosan activity

Author

Listed:
  • Colin W. Levy

    (Krebs Institute for Biomolecular Research, University of Sheffield)

  • Anna Roujeinikova

    (Krebs Institute for Biomolecular Research, University of Sheffield)

  • Svetlana Sedelnikova

    (Krebs Institute for Biomolecular Research, University of Sheffield)

  • Patrick J. Baker

    (Krebs Institute for Biomolecular Research, University of Sheffield)

  • Antoine R. Stuitje

    (Institute of Molecular Biological Studies (IMBW), Vrije Universiteit)

  • Antoni R. Slabas

    (University of Durham)

  • David W. Rice

    (Krebs Institute for Biomolecular Research, University of Sheffield)

  • John B. Rafferty

    (Krebs Institute for Biomolecular Research, University of Sheffield)

Abstract

Triclosan (5-chloro-2-(2,4-dichlorophenoxy) phenol) has been used for more than 30 years as a general antibacterial and antifungal agent, and is found in formulations as diverse as toothpastes, cosmetics, antiseptic soaps, carpets, plastic kitchenware and toys. It has recently been suggested that triclosan blocks lipid biosynthesis by specifically inhibiting the enzyme enoyl-acyl carrier protein reductase (ENR)1. We have carried out a structural analysis and inhibition experiments on a complex of ENR from the bacterium Escherichia coli with triclosan and NAD+. We find that triclosan acts as a site-directed, very potent inhibitor of the enzyme by mimicking its natural substrate.

Suggested Citation

  • Colin W. Levy & Anna Roujeinikova & Svetlana Sedelnikova & Patrick J. Baker & Antoine R. Stuitje & Antoni R. Slabas & David W. Rice & John B. Rafferty, 1999. "Molecular basis of triclosan activity," Nature, Nature, vol. 398(6726), pages 383-384, April.
    • Handle: RePEc:nat:nature:v:398:y:1999:i:6726:d:10.1038_18803
    DOI: 10.1038/18803
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    Cited by:

    1. Gurpreet Singh Dhillon & Surinder Kaur & Rama Pulicharla & Satinder Kaur Brar & Maximiliano Cledón & Mausam Verma & Rao Y. Surampalli, 2015. "Triclosan: Current Status, Occurrence, Environmental Risks and Bioaccumulation Potential," IJERPH, MDPI, vol. 12(5), pages 1-28, May.
    2. Minjin Lee & Joo-Hyon Kim & Daeyeop Lee & Jaewoo Kim & Hyunwoo Lim & Jungkwan Seo & Young-Kwon Park, 2018. "Health Risk Assessment on Hazardous Ingredients in Household Deodorizing Products," IJERPH, MDPI, vol. 15(4), pages 1-12, April.
    3. María Gemma Albendín & Vanessa Aranda & María Dolores Coello & Carmen González-Gómez & Rocío Rodríguez-Barroso & José María Quiroga & Juana María Arellano, 2021. "Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina," IJERPH, MDPI, vol. 18(20), pages 1-15, October.

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