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brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes

Author

Listed:
  • Maki Minami

    (Institute of Molecular and Cellular Biosciences, University of Tokyo)

  • Noriyuki Kinoshita

    (Tokyo Metropolitan Institute for Neuroscience)

  • Yuko Kamoshida

    (Institute of Molecular and Cellular Biosciences, University of Tokyo)

  • Hiromu Tanimoto

    (Institute of Molecular and Cellular Biosciences, University of Tokyo)

  • Tetsuya Tabata

    (Institute of Molecular and Cellular Biosciences, University of Tokyo)

Abstract

Growth and patterning of the Drosophila wing is controlled in part by the long-range organizing activities of the Decapentaplegic protein (Dpp)1,2,3,4. Dpp is synthesized by cells that line the anterior side of the anterior/posterior compartment border of the wing imaginal disc. From this source, Dpp is thought to generate a concentration gradient that patterns both anterior and posterior compartments. Among the gene targets that it regulates are optomotor blind (omb)5, spalt (sal)6, and daughters against dpp (dad)7. We report here the molecular cloning of brinker (brk), and show that brk expression is repressed by dpp. brk encodes, a protein that negatively regulates Dpp-dependent genes. Expression of brk in Xenopus embryos indicates that brk can also repress the targets of a vertebrate homologue of Dpp, bone morphogenetic protein 4 (BMP-4). The evolutionary conservation of Brk function underscores the importance of its negative role in proportioning Dpp activity.

Suggested Citation

  • Maki Minami & Noriyuki Kinoshita & Yuko Kamoshida & Hiromu Tanimoto & Tetsuya Tabata, 1999. "brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes," Nature, Nature, vol. 398(6724), pages 242-246, March.
    • Handle: RePEc:nat:nature:v:398:y:1999:i:6724:d:10.1038_18451
    DOI: 10.1038/18451
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    Cited by:

    1. Fisun Hamaratoglu & Aitana Morton de Lachapelle & George Pyrowolakis & Sven Bergmann & Markus Affolter, 2011. "Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc," PLOS Biology, Public Library of Science, vol. 9(10), pages 1-17, October.

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