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A mammalian protein with specific demethylase activity for mCpG DNA

Author

Listed:
  • Sanjoy K. Bhattacharya

    (McGill University)

  • Shyam Ramchandani

    (McGill University)

  • Nadia Cervoni
  • Moshe Szyf

Abstract

DNA-methylation patterns are important for regulating genome functions, and are determined by the enzymatic processes of methylation and demethylation. The demethylating enzyme has now been identified: a mammalian complementary DNA encodes a methyl-CpG-binding domain, bears a demethylase activity that transforms methylated cytosine bases to cytosine, and demethylates a plasmid when the cDNA is translated or transiently transfected into human embryonal kidney cells in vitro. The discovery of this DNA demethylase should provide a basis for the molecular and developmental analysis of the role of DNA methylation and demethylation.

Suggested Citation

  • Sanjoy K. Bhattacharya & Shyam Ramchandani & Nadia Cervoni & Moshe Szyf, 1999. "A mammalian protein with specific demethylase activity for mCpG DNA," Nature, Nature, vol. 397(6720), pages 579-583, February.
    • Handle: RePEc:nat:nature:v:397:y:1999:i:6720:d:10.1038_17533
    DOI: 10.1038/17533
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