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Secondary V(D)J recombination in B-1 cells

Author

Listed:
  • Xiao-Feng Qin

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Stephan Schwers

    (Institute for Genetics, University of Cologne)

  • Wong Yu

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Fotini Papavasiliou

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Heikyung Suh

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute The Rockefeller University)

  • Andre Nussenzweig

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health)

  • Klaus Rajewsky

    (Institute for Genetics, University of Cologne)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute The Rockefeller University)

Abstract

B-1 B cells are a self-renewing population of B cells that differ from conventional B cells (B-2 cells) in that they are particularly predisposed to auto-antibody production1,2,3. Although much is known about the signalling pathways that control B-1-cell growth and development (reviewed in ref. 4), less is known about why these cells are prone to produce autoreactive antibodies. Here we show that B-1 cells, like germinal-centre B cells5,6,7,8, can express recombinase-activating genes 1 and 2 (RAG1 and RAG2) and undergo secondary V(D)J recombination of immunoglobulin genes. In addition, B cells from autoimmune-prone NZB mice show high levels of RAG messenger RNA and recombination. We propose that secondary immunoglobulin-gene rearrangements outside organized lymphoid organs may contribute to the development of autoreactive antibodies.

Suggested Citation

  • Xiao-Feng Qin & Stephan Schwers & Wong Yu & Fotini Papavasiliou & Heikyung Suh & Andre Nussenzweig & Klaus Rajewsky & Michel C. Nussenzweig, 1999. "Secondary V(D)J recombination in B-1 cells," Nature, Nature, vol. 397(6717), pages 355-359, January.
    • Handle: RePEc:nat:nature:v:397:y:1999:i:6717:d:10.1038_16933
    DOI: 10.1038/16933
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