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Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

Author

Listed:
  • Richard A. Alm

    (Astra Research Center Boston)

  • Lo-See L. Ling

    (Genome Therapeutics Corporation)

  • Donald T. Moir

    (Genome Therapeutics Corporation)

  • Benjamin L. King

    (Astra Research Center Boston)

  • Eric D. Brown

    (Astra Research Center Boston)

  • Peter C. Doig

    (Astra Research Center Boston)

  • Douglas R. Smith

    (Genome Therapeutics Corporation)

  • Brian Noonan

    (Astra Research Center Boston)

  • Braydon C. Guild

    (Genome Therapeutics Corporation)

  • Boudewijn L. deJonge

    (Astra Research Center Boston)

  • Gilles Carmel

    (Genome Therapeutics Corporation)

  • Peter J. Tummino

    (Astra Research Center Boston)

  • Anthony Caruso

    (Genome Therapeutics Corporation)

  • Maria Uria-Nickelsen

    (Astra Research Center Boston)

  • Debra M. Mills

    (Genome Therapeutics Corporation)

  • Cameron Ives

    (Astra Research Center Boston)

  • Rene Gibson

    (Genome Therapeutics Corporation)

  • David Merberg

    (Astra Research Center Boston)

  • Scott D. Mills

    (Astra Research Center Boston)

  • Qin Jiang

    (University of Alberta)

  • Diane E. Taylor

    (University of Alberta)

  • Gerald F. Vovis

    (Genome Therapeutics Corporation)

  • Trevor J. Trust

    (Astra Research Center Boston)

Abstract

Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma1. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host2,3 and to participate in the lifelong chronicity of infection4. Here we compare the complete genomic sequences of two unrelated H. pylori isolates. This is, to our knowledge, the first such genomic comparison. H. pylori was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region.

Suggested Citation

  • Richard A. Alm & Lo-See L. Ling & Donald T. Moir & Benjamin L. King & Eric D. Brown & Peter C. Doig & Douglas R. Smith & Brian Noonan & Braydon C. Guild & Boudewijn L. deJonge & Gilles Carmel & Peter , 1999. "Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori," Nature, Nature, vol. 397(6715), pages 176-180, January.
    • Handle: RePEc:nat:nature:v:397:y:1999:i:6715:d:10.1038_16495
    DOI: 10.1038/16495
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    Cited by:

    1. Jiang Tan & Hui-Zhen Fu & Yuh-Shan Ho, 2014. "A bibliometric analysis of research on proteomics in Science Citation Index Expanded," Scientometrics, Springer;Akadémiai Kiadó, vol. 98(2), pages 1473-1490, February.

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