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Kainate receptors mediate synaptic transmission between cones and ‘Off’ bipolar cells in a mammalian retina

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  • Steven H. DeVries

    (University of Texas Houston Health Science Center)

  • Eric A. Schwartz

    (University of Chicago)

Abstract

Light produces a graded hyperpolarization in retinal photoreceptors1,2 that decreases their release of synaptic neurotransmitter3,4. Cone photoreceptors use glutamate5,6 as a neurotransmitter with which to communicate with two types of bipolar cell. Activation of metabotropic glutamate receptors in ‘On’ bipolar cells7,8 initiates a second-messenger cascade that can amplify small synaptic inputs from cones. In contrast, it is not known how the ionotropic glutamate receptors that are activated in ‘Off’ bipolar cells9,10 are optimized for transmitting small, graded signals. Here we show, by recording from a cone and a synaptically connected ‘Off’ bipolar cell in slices of retina from the ground squirrel, that transmission is mediated by glutamate receptors of the kainate-preferring subtype. In the dark, a cone releases sufficient neurotransmitter to desensitize most postsynaptic kainate receptors. The small postsynaptic current that persists (

Suggested Citation

  • Steven H. DeVries & Eric A. Schwartz, 1999. "Kainate receptors mediate synaptic transmission between cones and ‘Off’ bipolar cells in a mammalian retina," Nature, Nature, vol. 397(6715), pages 157-160, January.
    • Handle: RePEc:nat:nature:v:397:y:1999:i:6715:d:10.1038_16462
    DOI: 10.1038/16462
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    Cited by:

    1. Chad P. Grabner & Daiki Futagi & Jun Shi & Vytas Bindokas & Katsunori Kitano & Eric A. Schwartz & Steven H. DeVries, 2023. "Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Andrew Jo & Sercan Deniz & Jian Xu & Robert M. Duvoisin & Steven H. DeVries & Yongling Zhu, 2023. "A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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