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Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

Author

Listed:
  • Robert M. Pitti

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Scot A. Marsters

    (Molecular Biology, and Immunology, Genentech Inc.)

  • David A. Lawrence

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Margaret Roy

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Frank C. Kischkel

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Patrick Dowd

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Arthur Huang

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Christopher J. Donahue

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Steven W. Sherwood

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Daryl T. Baldwin

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Paul J. Godowski

    (Molecular Biology, and Immunology, Genentech Inc.)

  • William I. Wood

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Austin L. Gurney

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Kenneth J. Hillan

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Robert L. Cohen

    (Molecular Biology, and Immunology, Genentech Inc.)

  • Audrey D. Goddard

    (Molecular Biology, and Immunology, Genentech Inc.)

  • David Botstein

    (Stanford University)

  • Avi Ashkenazi

    (Molecular Biology, and Immunology, Genentech Inc.)

Abstract

Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apo1/CD95 (ref. 1). One important role of FasL and Fas is to mediate immune-cytotoxic killing of cells that are potentially harmful to the organism, such as virus-infected or tumour cells1. Here we report the discovery of a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds to FasL and inhibits FasL-induced apoptosis. The DcR3 gene was amplified in about half of 35 primary lung and colon tumours studied, and DcR3 messenger RNA was expressed in malignant tissue. Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL.

Suggested Citation

  • Robert M. Pitti & Scot A. Marsters & David A. Lawrence & Margaret Roy & Frank C. Kischkel & Patrick Dowd & Arthur Huang & Christopher J. Donahue & Steven W. Sherwood & Daryl T. Baldwin & Paul J. Godow, 1998. "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer," Nature, Nature, vol. 396(6712), pages 699-703, December.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6712:d:10.1038_25387
    DOI: 10.1038/25387
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    Cited by:

    1. Rocci, Roberto & Vichi, Maurizio, 2008. "Two-mode multi-partitioning," Computational Statistics & Data Analysis, Elsevier, vol. 52(4), pages 1984-2003, January.

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