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p53 polymorphism and risk of cervical cancer

Author

Listed:
  • Allan Hildesheim

    (National Cancer Institute)

  • Mark Schiffman

    (National Cancer Institute)

  • Louise A. Brinton

    (National Cancer Institute)

  • Joseph F. Fraumeni

    (National Cancer Institute)

  • Rolando Herrero

    (International Agency for Research on Cancer)

  • M. Concepcion Bratti

    (Caja Costarriciense de Seguro Social)

  • Peter Schwartz

    (Yale University School of Medicine)

  • Rodrigue Mortel

    (Milton S. Hershey Medical Center)

  • Willard Barnes

    (Georgetown University Lombardi Cancer Center)

  • Mitchell Greenberg

    (Graduate Hospital)

  • Larry McGowan

    (George Washington University Medical Center)

  • David R. Scott

    (Kaiser Permanente)

  • Maureen Martin

    (Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC)

  • Jesus E. Herrera

    (Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC)

  • Mary Carrington

    (Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC)

Abstract

Storey and co-workers 1 have reported data suggesting that individuals homozygous for arginine at residue 72 of p53 (p53Arg) are about seven times more susceptible to invasive cervical cancer than individuals who carry at least one proline at that position (p53Pro)1. These preliminary data were supported by in vitro evidence demonstrating that the E6 oncoprotein of human papilloma virus (HPV) degrades p53Arg more efficiently than p53Pro. We have now tested specimens from a total of 1,309 women in three studies for p53 polymorphisms. We find that p53Arg is not associated with an increased risk of preinvasive or invasive cervical neoplasia; indeed, there is a tendency for p53Arg to be associated with a decreased risk of neoplasia.

Suggested Citation

  • Allan Hildesheim & Mark Schiffman & Louise A. Brinton & Joseph F. Fraumeni & Rolando Herrero & M. Concepcion Bratti & Peter Schwartz & Rodrigue Mortel & Willard Barnes & Mitchell Greenberg & Larry McG, 1998. "p53 polymorphism and risk of cervical cancer," Nature, Nature, vol. 396(6711), pages 531-532, December.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6711:d:10.1038_25040
    DOI: 10.1038/25040
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