IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v396y1998i6711d10.1038_25034.html
   My bibliography  Save this article

p53 polymorphism and risk of cervical cancer

Author

Listed:
  • Åslaug Helland

    (Institute of Cancer Research, Norwegian Radium Hospital)

  • Anita Langerød

    (Institute of Cancer Research, Norwegian Radium Hospital)

  • Hilde Johnsen

    (Institute of Cancer Research, Norwegian Radium Hospital)

  • Anne O. Olsen

    (Section of Epidemiology, National Institute of Public Health)

  • Eva Skovlund

    (University of Oslo)

  • Anne-Lise Børresen-Dale

    (Institute of Cancer Research, Norwegian Radium Hospital)

Abstract

Storey and co-workers 1 recently presented results indicating that the allele encoding arginine in the codon-72 polymorphism of the p53 gene represents a significant risk factor in the development of cancers associated with human papilloma virus (HPV). The form of the p53 protein carrying an arginine residue at this position was found to be significantly more susceptible to degradation by the HPV E6 protein than by the proline form. Genotype analysis of 30 cervical tumours and 12 skin carcinomas revealed that the homozygous Arg/Arg genotype was overrepresented compared with 41 controls. We have now analysed this polymorphism in leukocyte DNA from a larger sample of cancer patients and controls but have found no significant overrepresentation of this genotype.

Suggested Citation

  • Åslaug Helland & Anita Langerød & Hilde Johnsen & Anne O. Olsen & Eva Skovlund & Anne-Lise Børresen-Dale, 1998. "p53 polymorphism and risk of cervical cancer," Nature, Nature, vol. 396(6711), pages 530-531, December.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6711:d:10.1038_25034
    DOI: 10.1038/25034
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/25034
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/25034?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:396:y:1998:i:6711:d:10.1038_25034. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.