IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v396y1998i6709d10.1038_24614.html
   My bibliography  Save this article

Ethanol consumption and resistance are inversely related to neuropeptide Y levels

Author

Listed:
  • Todd E. Thiele

    (University of Washington)

  • Donald J. Marsh

    (University of Washington)

  • Linda Ste. Marie

    (University of Washington)

  • Ilene L. Bernstein

    (University of Washington)

  • Richard D. Palmiter

    (University of Washington)

Abstract

Genetic linkage analysis of rats that were selectively bred for alcohol preference identified a chromosomal region that includes the neuropeptide Y (NPY) gene1. Alcohol-preferring rats have lower levels of NPY in several brain regions compared with alcohol-non-preferring rats2. We therefore studied alcohol consumption by mice that completely lack NPY as a result of targeted gene disruption3. Here we report that NPY-deficient mice show increased consumption, compared with wild-type mice, of solutions containing 6%, 10% and 20% (v/v) ethanol. NPY-deficient mice are also less sensitive to the sedative/hypnotic effects of ethanol, as shown by more rapid recovery from ethanol-induced sleep, even though plasma ethanol concentrations do not differ significantly from those of controls. In contrast, transgenic mice that overexpress a marked NPY gene in neurons that usually express it have a lower preference for ethanol and are more sensitive to the sedative/hypnotic effects of this drug than controls. These data are direct evidence that alcohol consumption and resistance are inversely related to NPY levels in the brain.

Suggested Citation

  • Todd E. Thiele & Donald J. Marsh & Linda Ste. Marie & Ilene L. Bernstein & Richard D. Palmiter, 1998. "Ethanol consumption and resistance are inversely related to neuropeptide Y levels," Nature, Nature, vol. 396(6709), pages 366-369, November.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6709:d:10.1038_24614
    DOI: 10.1038/24614
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/24614
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/24614?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. David J Marcus & Angela N Henderson-Redmond & Maciej Gonek & Michael L Zee & Jill C Farnsworth & Randa A Amin & Mary-Jeanette Andrews & Brian J Davis & Ken Mackie & Daniel J Morgan, 2017. "Mice expressing a “hyper-sensitive” form of the CB1 cannabinoid receptor (CB1) show modestly enhanced alcohol preference and consumption," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-17, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:396:y:1998:i:6709:d:10.1038_24614. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.