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Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A

Author

Listed:
  • S. Ait-Si-Ali

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • S. Ramirez

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • F.-X. Barre

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • F. Dkhissi

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • L. Magnaghi-Jaulin

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • J. A. Girault

    (INSERM U114, Collège de France)

  • P. Robin

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • M. Knibiehler

    (IPBS, CNRS UPR 9062, Université Paul Sabatier)

  • L. L. Pritchard

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • B. Ducommun

    (INSERM U114, Collège de France)

  • D. Trouche

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

  • A. Harel-Bellan

    (Laboratoire Oncogénèse, Différenciation et Transduction du Signal)

Abstract

Transforming viral proteins such as E1A force cells through the restriction point of the cell cycle into S phase by forming complexes with two cellular proteins1,2,3: the retinoblastoma protein (Rb)4, a transcriptional co-repressor5, and CBP/p300 (ref. 6), a transcriptional co-activator7,8,9. These two proteins locally influence chromatin structure: Rb recruits a histone deacetylase10,11,12, whereas CBP is a histone acetyltransferase13,14. Progression through the restriction point is triggered by phosphorylation of Rb, leading to disruption of Rb-associated repressive complexes and allowing the activation of S-phase genes15. Here we show that CBP, like Rb, is controlled by phosphorylation at the G1/S boundary, increasing its histone acetyltransferase activity. This enzymatic activation is mimicked by E1A.

Suggested Citation

  • S. Ait-Si-Ali & S. Ramirez & F.-X. Barre & F. Dkhissi & L. Magnaghi-Jaulin & J. A. Girault & P. Robin & M. Knibiehler & L. L. Pritchard & B. Ducommun & D. Trouche & A. Harel-Bellan, 1998. "Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A," Nature, Nature, vol. 396(6707), pages 184-186, November.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6707:d:10.1038_24190
    DOI: 10.1038/24190
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