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The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex

Author

Listed:
  • Ilil Carmi

    (University of California, Berkeley)

  • Jennifer B. Kopczynski

    (University of California, Berkeley
    Exelixis Pharmaceuticals, Inc.)

  • Barbara J. Meyer

    (University of California, Berkeley)

Abstract

Organisms in many phyla determine sexual fate by distinguishing one X chromosome from two. Here we use the model organism Caenorhabditis elegans to dissect such an X-chromosome-counting mechanism in molecular detail. In this nematode, several genes on the X chromosome called X signal elements communicate X-chromosome dose by controlling the activity of the sex-determination gene xol-1 (refs 1, 2). xol-1 specifies male (XO) fatewhen active and hermaphrodite (XX) fate when inactive3,4. The only X signal element described so far represses xol-1 post-transcriptionally, but xol-1 is repressed in XX animals by transcriptional and post-transcriptional mechanisms2. Here we identify a nuclear-hormone-receptor homologue, SEX-1, that regulates the transcription of xol-1. We show that sex-1 is vital to X-chromosome counting: changing sex-1 gene dose in XX or XO embryos causes sexual transformation and death from inadequate dosage compensation (the hermaphrodite-specific process that equalizes X-gene expression between the sexes5). The SEX-1 protein acts directly on xol-1, associating with its promoter in vivo and repressing xol-1 transcription in XX embryos. Thus, xol-1 is the direct molecular target of the primary sex-determination signal, and the dose of a nuclear hormone receptor helps to communicate X-chromosome number to determine nematode sex.

Suggested Citation

  • Ilil Carmi & Jennifer B. Kopczynski & Barbara J. Meyer, 1998. "The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex," Nature, Nature, vol. 396(6707), pages 168-173, November.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6707:d:10.1038_24164
    DOI: 10.1038/24164
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