IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v395y1998i6702d10.1038_26982.html
   My bibliography  Save this article

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Author

Listed:
  • Robert A. Cavallo

    (University of North Carolina)

  • Rachel T. Cox

    (University of North Carolina)

  • Melissa M. Moline

    (Molecular Biology and Cell Biology, Northwestern University)

  • Jeroen Roose

    (University Hospital)

  • Gordon A. Polevoy

    (University of North Carolina)

  • Hans Clevers

    (University Hospital)

  • Mark Peifer

    (University of North Carolina)

  • Amy Bejsovec

    (Molecular Biology and Cell Biology, Northwestern University)

Abstract

Wingless/Wnt signalling directs cell-fate choices during embryonic development1,2. Inappropriate reactivation of the pathway causes cancer3,4,5. In Drosophila, signal transduction from Wingless stabilizes cytosolic Armadillo1, which then forms a bipartite transcription factor with the HMG-box protein Drosophila Tcf (dTcf) and activates expression of Wingless-responsive genes6,7,8. Here we report that in the absence of Armadillo, dTcf acts as a transcriptional repressor of Wingless-responsive genes, and we show that Groucho acts as a corepressor in this process. Reduction of dTcf activity partially suppresses wingless and armadillo mutant phenotypes, leading to derepression of Wingless-responsive genes. Furthermore, overexpression of wild-type dTcf enhances the phenotype of a weak wingless allele. Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity.

Suggested Citation

  • Robert A. Cavallo & Rachel T. Cox & Melissa M. Moline & Jeroen Roose & Gordon A. Polevoy & Hans Clevers & Mark Peifer & Amy Bejsovec, 1998. "Drosophila Tcf and Groucho interact to repress Wingless signalling activity," Nature, Nature, vol. 395(6702), pages 604-608, October.
    • Handle: RePEc:nat:nature:v:395:y:1998:i:6702:d:10.1038_26982
    DOI: 10.1038/26982
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/26982
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/26982?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:395:y:1998:i:6702:d:10.1038_26982. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.