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Does vitamin C have a pro-oxidant effect?

Author

Listed:
  • Ian D. Podmore

    (Centre for Mechanisms of Human Toxicity, University of Leicester)

  • Helen R. Griffiths

    (Centre for Mechanisms of Human Toxicity, University of Leicester)

  • Karl E. Herbert

    (Centre for Mechanisms of Human Toxicity, University of Leicester)

  • Nalini Mistry

    (Centre for Mechanisms of Human Toxicity, University of Leicester)

  • Pratibha Mistry

    (Centre for Mechanisms of Human Toxicity, University of Leicester)

  • Joseph Lunec

    (Centre for Mechanisms of Human Toxicity, University of Leicester)

Abstract

Podmore et al. reply — In our Scientific Correspondence 1 we reported changes in lymphocyte DNA to two established ‘markers’ of oxidative DNA damage after daily supplementation of healthy volunteers with 500 mg vitamin C for six weeks. One marker, 8-oxoadenine, increased, whereas the other, 8-oxoguanine, decreased. On this basis, vitamin C seems to act as both a pro-oxidant and an antioxidant in vivo. Our contribution has stimulated many comments, most of which were addressed in our original manuscript to Nature, which was shortened for publication at the editors' request. The full details are available from us on request.

Suggested Citation

  • Ian D. Podmore & Helen R. Griffiths & Karl E. Herbert & Nalini Mistry & Pratibha Mistry & Joseph Lunec, 1998. "Does vitamin C have a pro-oxidant effect?," Nature, Nature, vol. 395(6699), pages 232-232, September.
    • Handle: RePEc:nat:nature:v:395:y:1998:i:6699:d:10.1038_26141
    DOI: 10.1038/26141
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