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p19ARF links the tumour suppressor p53 to Ras

Author

Listed:
  • Ignacio Palmero

    (Centro Nacional de Biotecnologa, CSIC, Campus de Cantoblanco)

  • Cristina Pantoja

    (Centro Nacional de Biotecnologa, CSIC, Campus de Cantoblanco)

  • Manuel Serrano

    (Centro Nacional de Biotecnologa, CSIC, Campus de Cantoblanco)

Abstract

Normal healthy cells possess safeguard mechanisms that sense oncogenic signals and trigger anti-tumorigenic responses that limit the proliferative potential of cells harbouring active oncogenes1. In particular, expression of the Ras oncogene in normal primary cells causes a cell-cycle arrest that involves the activation of the tumoursuppressor protein p53 (ref. 2). It has recently been reported that the tumour-suppressor p19ARF can activate p53 (3–5). Here we show that p19ARF in the mouse (the human homologue is called p14ARF) is essential for the activation of p53 in response to oncogenic Ras. These results, together with the finding that p19ARF does not mediate the activation of p53 by DNA damage6, dissociate the activation of p53 into two pathways: one pathway is induced by DNA damage and is independent of p19ARF, whereas the other pathway is induced by oncogenic Ras and is dependent on p19ARF.

Suggested Citation

  • Ignacio Palmero & Cristina Pantoja & Manuel Serrano, 1998. "p19ARF links the tumour suppressor p53 to Ras," Nature, Nature, vol. 395(6698), pages 125-126, September.
    • Handle: RePEc:nat:nature:v:395:y:1998:i:6698:d:10.1038_25870
    DOI: 10.1038/25870
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    1. Hadas Sibony-Benyamini & Emil Aamar & David Enshell-Seijffers, 2023. "Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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