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Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

Author

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  • Landin Boring

    (Gladstone Institute of Cardiovascular Disease
    Cardiovascular Research Institute, University of California)

  • Jennifa Gosling

    (Gladstone Institute of Cardiovascular Disease)

  • Michael Cleary

    (Gladstone Institute of Cardiovascular Disease)

  • Israel F. Charo

    (Gladstone Institute of Cardiovascular Disease
    Cardiovascular Research Institute, University of California
    University of California)

Abstract

Chemokines are proinflammatory cytokines that function in leukocyte chemoattraction and activation and have recently been shown to block the HIV-1 infection of target cells through interactions with chemokine receptors1,2. In addition to their function in viral disease, chemokines have been implicated in the pathogenesis of atherosclerosis. Expression of the CC chemokine monocyte chemoattractant protein-1 (MCP-1) is upregulated in human atherosclerotic plaques3,4, in arteries of primates on a hypercholesterolaemic diet5 and in vascular endothelial and smooth muscle cells exposed to minimally modified lipids5,6. To determine whether MCP-1 is causally related to the development of atherosclerosis, we generated mice that lack CCR2, the receptor for MCP-1 (ref. 7), and crossed them with apolipoprotein (apo) E-null mice8,9,10 which develop severe atherosclerosis. Here we show that the selective absence of CCR2 decreases lesion formation markedly in apoE−/− mice but has no effect on plasma lipid or lipoprotein concentrations. These data reveal a role for MCP-1 in the development of early atherosclerotic lesions and suggest that upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation.

Suggested Citation

  • Landin Boring & Jennifa Gosling & Michael Cleary & Israel F. Charo, 1998. "Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis," Nature, Nature, vol. 394(6696), pages 894-897, August.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6696:d:10.1038_29788
    DOI: 10.1038/29788
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    Cited by:

    1. Masanori Itakura & Kosuke Yamaguchi & Roma Kitazawa & Sei-Young Lim & Yusuke Anan & Jun Yoshitake & Takahiro Shibata & Lumi Negishi & Hikari Sugawa & Ryoji Nagai & Koji Uchida, 2022. "Histone functions as a cell-surface receptor for AGEs," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Man Luo & Jiaoxing Li & Xunsha Sun & Rong Lai & Yufang Wang & Xiaowei Xu & Wenli Sheng, 2015. "Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-10, December.
    3. Lewis Taylor & Maximillian Hugo Brodermann & David McCaffary & Asif Jilani Iqbal & David R Greaves, 2016. "Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-22, August.

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