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Awakening angels

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  • David Lane

    (Cancer Research Campaign Laboratories, University of Dundee)

Abstract

When mammalian cells are under stress they activate the tumour-suppressor gene p53. But how does the cell signal to p53 that it is under attack? A new study implicates the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage and can bind p53. Damaged cells that don't contain DNA-PK accumulate an inactive form of p53, indicating that DNA-PK is crucial for the activation of p53.

Suggested Citation

  • David Lane, 1998. "Awakening angels," Nature, Nature, vol. 394(6694), pages 616-617, August.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6694:d:10.1038_29166
    DOI: 10.1038/29166
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