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Triclosan targets lipid synthesis

Author

Listed:
  • Laura M. McMurry

    (Tufts University School of Medicine)

  • Margret Oethinger

    (Tufts University School of Medicine)

  • Stuart B. Levy

    (Tufts University School of Medicine)

Abstract

Triclosan is a broad-spectrum antibacterial and antifungal agent1,2, which acts by previously undetermined mechanisms, that is used in products such as antiseptic soaps, toothpastes, fabrics and plastics. Here we show that triclosan blocks lipid synthesis in Escherichia coli, and that mutations in, or overexpression of, the gene fabI (which encodes enoyl reductase, involved in fatty acid synthesis) prevents this blockage. This is, to our knowledge, the first evidence that triclosan acts on a specific bacterial target, rather than as a nonspecific ‘biocide’.

Suggested Citation

  • Laura M. McMurry & Margret Oethinger & Stuart B. Levy, 1998. "Triclosan targets lipid synthesis," Nature, Nature, vol. 394(6693), pages 531-532, August.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6693:d:10.1038_28970
    DOI: 10.1038/28970
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    Cited by:

    1. Gurpreet Singh Dhillon & Surinder Kaur & Rama Pulicharla & Satinder Kaur Brar & Maximiliano Cledón & Mausam Verma & Rao Y. Surampalli, 2015. "Triclosan: Current Status, Occurrence, Environmental Risks and Bioaccumulation Potential," IJERPH, MDPI, vol. 12(5), pages 1-28, May.
    2. Qiu E. Yang & Xiaodan Ma & Minchun Li & Mengshi Zhao & Lingshuang Zeng & Minzhen He & Hui Deng & Hanpeng Liao & Christopher Rensing & Ville-Petri Friman & Shungui Zhou & Timothy R. Walsh, 2024. "Evolution of triclosan resistance modulates bacterial permissiveness to multidrug resistance plasmids and phages," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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