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FYVE fingers bind PtdIns(3)P

Author

Listed:
  • Jean-Michel Gaullier

    (The Norwegian Radium Hospital)

  • Anne Simonsen

    (The Norwegian Radium Hospital)

  • Antonello D'Arrigo
  • Bjørn Bremnes
  • Harald Stenmark

    (The Norwegian Radium Hospital)

  • Rein Aasland

    (University of Bergen)

Abstract

The membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) is constitutively produced by yeast and higher eukaryotes through the phosphorylation of phosphatidylinositol by phosphatidylinositol-3-OH kinase1 (PI(3)K). PtdIns(3)P is important for vesicular transport1, but little is known about how it acts, and proteins that specifically recognize it have not yet been identified. Here we identify the FYVE finger2, an evolutionarily conserved double-zinc-binding domain (see Supplementary information), as a protein structure that binds to PtdIns(3)P with high specificity.

Suggested Citation

  • Jean-Michel Gaullier & Anne Simonsen & Antonello D'Arrigo & Bjørn Bremnes & Harald Stenmark & Rein Aasland, 1998. "FYVE fingers bind PtdIns(3)P," Nature, Nature, vol. 394(6692), pages 432-433, July.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6692:d:10.1038_28767
    DOI: 10.1038/28767
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