IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v394y1998i6689d10.1038_28184.html
   My bibliography  Save this article

Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro

Author

Listed:
  • A. Draguhn

    (The Medical School, University of Birmingham
    Institut für Physiologie der Charité, Humboldt-Univesität zu Berlin, Tucholskystr. 2)

  • R. D. Traub

    (The Medical School, University of Birmingham)

  • D. Schmitz

    (Institut für Physiologie der Charité, Humboldt-Univesität zu Berlin, Tucholskystr. 2)

  • J. G. R. Jefferys

    (The Medical School, University of Birmingham)

Abstract

Coherent oscillations, in which ensembles of neurons fire in a repeated and synchronous manner, are thought to be important in higher brain functions. In the hippocampus, these discharges are categorized according to their frequency as theta (4–10 Hz)1, gamma (20–80 Hz)2 and high-frequency (∼200 Hz)3,4,5 discharges, and they occur in relation to different behavioural states. The synaptic bases of theta and gamma rhythms have been extensively studied6,7 but the cellular bases for high-frequency oscillations are not understood. Here we report that high-frequency network oscillations are present in rat brain slices in vitro, occurring as a brief series of repetitive population spikes at 150–200 Hz in all hippocampal principal cell layers. Moreover, this synchronous activity is not mediated through the more commonly studied modes of chemical synaptic transmission, but is in fact a result of direct electrotonic coupling of neurons, most likely through gap-junctional connections. Thus high-frequency oscillations synchronize the activity of electrically coupled subsets of principal neurons within the well-documented synaptic network of the hippocampus.

Suggested Citation

  • A. Draguhn & R. D. Traub & D. Schmitz & J. G. R. Jefferys, 1998. "Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro," Nature, Nature, vol. 394(6689), pages 189-192, July.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6689:d:10.1038_28184
    DOI: 10.1038/28184
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/BF28184
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/28184?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jalili, Mahdi, 2017. "Spike phase synchronization in multiplex cortical neural networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 466(C), pages 325-333.
    2. Erika R Kinjo & Guilherme S V Higa & Edgard Morya & Angela C Valle & Alexandre H Kihara & Luiz R G Britto, 2014. "Reciprocal Regulation of Epileptiform Neuronal Oscillations and Electrical Synapses in the Rat Hippocampus," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:394:y:1998:i:6689:d:10.1038_28184. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.