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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

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Listed:
  • Yohanns Bellaiche

    (Department of Genetics and)

  • Inge The

    (Department of Genetics and
    Howard Hughes Medical Institute, Harvard Medical School)

  • Norbert Perrimon

    (Department of Genetics and
    Howard Hughes Medical Institute, Harvard Medical School)

Abstract

Hedgehog (Hh) proteins act through both short-range and long-range signalling to pattern tissues during invertebrate and vertebrate development1. The mechanisms allowing Hedgehog to diffuse over a long distance and to exert its long-range effects are not understood. Here we identify a new Drosophila gene, named tout-velu, that is required for diffusion of Hedgehog. Characterization of tout-velu shows that it encodes an integral membrane protein that belongs to the EXT gene family. Members of thisfamily are involved in the human multiple exostoses syndrome, which affects bone morphogenesis2,3,4. Our results, together with the previous characterization of the role of IndianHedgehog in bone morphogenesis5,6,7, lead us to propose that themultiple exostoses syndrome is associated with abnormal diffusion of Hedgehog proteins. These results show the existence of a new conserved mechanism required for diffusion of Hedgehog.

Suggested Citation

  • Yohanns Bellaiche & Inge The & Norbert Perrimon, 1998. "Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion," Nature, Nature, vol. 394(6688), pages 85-88, July.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6688:d:10.1038_27932
    DOI: 10.1038/27932
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    1. Fabian Gude & Jurij Froese & Dominique Manikowski & Daniele Di Iorio & Jean-Noël Grad & Seraphine Wegner & Daniel Hoffmann & Melissa Kennedy & Ralf P. Richter & Georg Steffes & Kay Grobe, 2023. "Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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