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Molecular identification of a hyperpolarization-activated channel in sea urchin sperm

Author

Listed:
  • Renate Gauss
  • Reinhard Seifert
  • U. Benjamin Kaupp

    (Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich)

Abstract

Sea urchin eggs attract sperm through chemotactic peptides, which evoke complex changes in membrane voltage and in the concentrations of cyclic AMP, cyclic GMP and Ca2+ ions (see ref. 1 for a review). The intracellular signalling pathways and their cellular targets are largely unknown. We have now cloned, from sea urchin testis, the complementary DNA encoding a channel polypeptide, SPIH. Functional expression of SPIH gives rise to weakly K+-selective hyperpolarization-activated channels, whose activity is enhanced by the direct action of cAMP. Thus, SPIH is under the dual control of voltage and cAMP. The SPIH channel, which is confined to the sperm flagellum, may be involved in the control of flagellar beating. SPIH currents exhibit all the hallmarks of hyperpolarization-activated currents (Ih)2,3, which participate in the rhythmic firing of central neurons, control pacemaking in the heart, and curtail saturation by bright light in retinal photoreceptors2,3. Because of their sequence4 and functional properties, Ih channels form a class of their own within thesuperfamily of voltage-gated and cyclic-nucleotide-gated channels.

Suggested Citation

  • Renate Gauss & Reinhard Seifert & U. Benjamin Kaupp, 1998. "Molecular identification of a hyperpolarization-activated channel in sea urchin sperm," Nature, Nature, vol. 393(6685), pages 583-587, June.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6685:d:10.1038_31248
    DOI: 10.1038/31248
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    Cited by:

    1. Jesús Espinal-Enríquez & Alberto Darszon & Adán Guerrero & Gustavo Martínez-Mekler, 2014. "In Silico Determination of the Effect of Multi-Target Drugs on Calcium Dynamics Signaling Network Underlying Sea Urchin Spermatozoa Motility," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-11, August.
    2. Sabine Hummert & Susanne Thon & Thomas Eick & Ralf Schmauder & Eckhard Schulz & Klaus Benndorf, 2018. "Activation gating in HCN2 channels," PLOS Computational Biology, Public Library of Science, vol. 14(3), pages 1-18, March.
    3. Xiaolong Gao & Philipp A. M. Schmidpeter & Vladimir Berka & Ryan J. Durham & Chen Fan & Vasanthi Jayaraman & Crina M. Nimigean, 2022. "Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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