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Help for cytotoxic-T-cell responses is mediated by CD40 signalling

Author

Listed:
  • Sally R. M. Bennett

    (The Walter and Eliza Hall Institute of Medical Research
    The Cooperative Research Centre for Vaccine Technology at the Queensland Institute of Medical Research)

  • Francis R. Carbone

    (The Monash Medical School)

  • Freda Karamalis

    (The Walter and Eliza Hall Institute of Medical Research
    The Cooperative Research Centre for Vaccine Technology at the Queensland Institute of Medical Research)

  • Richard A. Flavell

    (The Section of Immunology and Howard Hughes Medical Institute, Yale University)

  • Jacques F. A. P. Miller

    (The Walter and Eliza Hall Institute of Medical Research)

  • William R. Heath

    (The Walter and Eliza Hall Institute of Medical Research)

Abstract

Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I major histocompatibility complex. CTLs are responsible for the killing of antigen-bearing target cells, such as virus-infected cells. Although CTL effectors can act alone when killing target cells, their differentiation from naive CD8-positive T cells is often dependent on ‘help’ from CD4-positive helper T (TH) cells1,2,3,4. Furthermore, for effective CTL priming, this help must be provided in a cognate manner, such that both the TH cell and the CTL recognize antigen on the same antigen-presenting cell2,4. One explanation for this requirement is that TH cells are needed to convert the antigen-presenting cell into a cell that is fully competent to prime CTL5. Here we show that signalling through CD40 on the antigen-presenting cells can replace the requirement for TH cells, indicating that T-cell ‘help’, at least for generation of CTLs by cross-priming, is mediated by signalling through CD40 on the antigen-presenting cell.

Suggested Citation

  • Sally R. M. Bennett & Francis R. Carbone & Freda Karamalis & Richard A. Flavell & Jacques F. A. P. Miller & William R. Heath, 1998. "Help for cytotoxic-T-cell responses is mediated by CD40 signalling," Nature, Nature, vol. 393(6684), pages 478-480, June.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6684:d:10.1038_30996
    DOI: 10.1038/30996
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