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RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Author

Listed:
  • Linda M. McLatchie

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
    The Novartis Institute for Medical Sciences)

  • Neil J. Fraser

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Martin J. Main

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Alan Wise

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Jason Brown

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Nicola Thompson

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Roberto Solari

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Melanie G. Lee

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

  • Steven M. Foord

    (Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre)

Abstract

Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.

Suggested Citation

  • Linda M. McLatchie & Neil J. Fraser & Martin J. Main & Alan Wise & Jason Brown & Nicola Thompson & Roberto Solari & Melanie G. Lee & Steven M. Foord, 1998. "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor," Nature, Nature, vol. 393(6683), pages 333-339, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6683:d:10.1038_30666
    DOI: 10.1038/30666
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