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Connexin 26 gene linked to a dominant deafness

Author

Listed:
  • Françoise Denoyelle

    (Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur
    Service d'ORL, Hôpital d'Enfants Armand-Trousseau)

  • Genevieve Lina-Granade

    (Laboratoire de Perception et Mécanismes Auditifs, CNRS UPRESA 5020, Université Claude Bernard Lyon I
    Hôpital Edouard Herriot)

  • Henri Plauchu

    (Laboratoire de Perception et Mécanismes Auditifs, CNRS UPRESA 5020, Université Claude Bernard Lyon I
    Hôpital Edouard Herriot)

  • Roberto Bruzzone

    (Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur)

  • Hassan Chaïb

    (Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur)

  • Fabienne Lévi-Acobas

    (Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur)

  • Dominique Weil

    (Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur)

  • Christine Petit

    (Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur)

Abstract

A high proportion of all cases of congenital deafness is causedby mutations in a gene coding for a gap-junction protein,connexin 26. The deafness associated with this gene, Cx26, is the autosomal recessive form, DFNB1(refs 1–3); its involvement in autosomal dominant forms of deafness has remained controversial4. Here we show that a mutation in Cx26 underlies the dominant form of deafness, DFNA3.

Suggested Citation

  • Françoise Denoyelle & Genevieve Lina-Granade & Henri Plauchu & Roberto Bruzzone & Hassan Chaïb & Fabienne Lévi-Acobas & Dominique Weil & Christine Petit, 1998. "Connexin 26 gene linked to a dominant deafness," Nature, Nature, vol. 393(6683), pages 319-320, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6683:d:10.1038_30639
    DOI: 10.1038/30639
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