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Methylation meets acetylation

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  • Timothy H. Bestor

    (College of Physicians and Surgeons of Columbia University)

Abstract

Females have two copies of the X chromosome, yet the genes on only one copy are active. Genes on the other copy are turned off by cytosine methylation. For the first time, a link has been found between this methylation process and acetylation of histones —the protein balls around which the DNA in chromosomes is wrapped. A protein called MeCP2, which binds only to methylated DNA sequences, exists in a complex with histone deacetylase, which removes acetyl groups from the histones, causing them to condense and become transcriptionally inactive.

Suggested Citation

  • Timothy H. Bestor, 1998. "Methylation meets acetylation," Nature, Nature, vol. 393(6683), pages 311-312, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6683:d:10.1038_30613
    DOI: 10.1038/30613
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